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(CNN) -- With a day to go before the world learns exactly what Lance Armstrong said to Oprah Winfrey about his involvement in doping as a professional cyclist, the cancer charity he founded urged the fallen star to come clean.

"We expect Lance to be completely truthful and forthcoming in his interview and with all of us in the cancer community," Livestrong said in a statement released Wednesday. "We expect we will have more to say at that time."

The U.S. Anti-Doping Agency accused Armstrong in October of involvement in a sophisticated doping program while he was a professional cyclist. The world governing body for cycling, the International Cycling Union, stripped Armstrong of his seven Tour de France titles following the report. He's also been banned from the sport for life.

Speaking with her close friend Gayle King on "CBS This Morning" on Tuesday, Winfrey appeared to confirm media reports that the former Tour de France champion acknowledged to her that he had used performance-enhancing substances.

Cyclist Lance Armstrong has been stripped of his seven Tour de France wins and banned from the tournament for life, the International Cycling Union announced Monday, October 22. Pictured, Armstrong addresses participants at The Livestrong Challenge Ride on Sunday. He stepped down as chairman of his Livestrong cancer charity on Wednesday, October 17.

Armstrong leads his teammates during the final stage of the 1999 Tour de France.

Armstrong, 17, competes in the Jeep Triathlon Grand Prix in 1988. He became a professional triathlete at age 16 and joined the U.S. National Cycling Team two years later.

In 1995, Armstrong wins the 18th stage of the Tour de France. He finished 36th overall and finished the race for the first time that year.

Armstrong rides for charity in May 1998 at the Ikon Ride for the Roses to benefit the Lance Armstrong Foundation. He established the foundation to benefit cancer research after being diagnosed with testicular cancer in 1996. After treatment, he was declared cancer-free in February 1997.

Armstrong takes his honor lap on the Champs-Élysées in Paris after winning the Tour de France for the first time in 1999.

After winning the 2000 Tour de France, Armstrong holds his son Luke on his shoulders.

Armstrong rides during the 18th stage of the 2001 Tour de France. He won the tour that year for the third consecutive time.

Armstrong celebrates winning the 10th stage of the Tour de France in 2001.

After winning the 2001 Tour de France, Armstrong presents President George W. Bush with a U.S. Postal Service yellow jersey and a replica of the bike he used to win the race.

Armstrong celebrates on the podium after winning the Tour de France by 61 seconds in 2003. It was his fifth consecutive win.

Jay Leno interviews Armstrong on "The Tonight Show" in 2003.

After his six consecutive Tour de France win in 2004, Armstrong attends a celebration in his honor in front of the Texas State Capitol in Austin.

Armstrong arrives at the 2005 American Music Awards in Los Angeles with his then-fiancee Sheryl Crow. The couple never made it down the aisle, splitting up the following year.

Armstrong holds up a paper displaying the number seven at the start of the Tour de France in 2005. He went on to win his seventh consecutive victory.

As a cancer survivor, Armstrong testifies during a Senate hearing in 2008 on Capitol Hill. The hearing focused on finding a cure for cancer in the 21st century.

In 2009, Armstrong suffers a broken collarbone after falling during a race in Spain along with more than a dozen other riders.

Young Armstrong fans write messages on the ground using yellow chalk ahead of the 2009 Tour de France. He came in third place that year.

Armstrong launches the three-day Livestrong Global Cancer Summit in 2009 in Dublin, Ireland. The event was organized by his foundation.

In May 2010, Armstrong crashes during the Amgen Tour of California and is taken to the hospital. That same day, he denied allegations of doping made by former teammate Floyd Landis.

Ahead of what he said would be his last Tour de France, Armstrong gears up for the start of the race in 2010.

Lance Armstrong looks back as he rides in a breakaway during the 2010 Tour de France.

Armstrong finishes 23rd in the 2010 Tour de France. He announced his retirement from the world of professional cycling in February 2011. He said he wants to devote more time to his family and the fight against cancer.

Armstrong's son Luke; twin daughters, Isabelle and Grace; and 1-year-old son, Max, stand outside the Radioshack team bus on a rest day during the 2010 Tour de France.

The frame of Armstrong's bike is engraved with the names of his four children at the time and the Spanish word for five, "cinco." His fifth child, Olivia, was born in October 2010.

In February 2012, Armstrong competes in the 70.3 Ironman Triathlon in Panama City. He went on to claim two Half Ironman triathlon titles by June. He got back into the sport after retiring from professional cycling.

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

Lance Armstrong over the years

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Photos: Lance Armstrong over the years

Armstrong could face more legal battles

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Reports: Armstrong admits steroid use

Winfrey's 2½-hour interview with Armstrong is to be aired Thursday and Friday on Winfrey's OWN cable network and on the Internet.

If true, such an admission would be a stunning reversal after years of vigorous denials, including lawsuits filed against accusers.

But it still will not be enough to reverse the lifetime ban and other sanctions that have kept him from participating in some triathlons -- the three-event sport he took up after retiring from cycling.

"Only when Mr. Armstrong makes a full confession under oath -- and tells the anti-doping authorities all he knows about doping activities -- can any legal and proper process for him to seek any reopening or reconsideration of his lifetime ban commence," said David Howman, director general of the World Anti-Doping Agency.

Winfrey said her team and Armstrong's camp had originally agreed not to leak details of the interview, and that she was surprised to find that not long after the interview, news reports were saying part of what Armstrong told her had "already been confirmed."

Winfrey declined to characterize Armstrong's answers or offer preview quotes, but said Armstrong came ready.

She said the former cyclist was forthcoming in what she described as an exhausting and intense interview taped Monday in Armstrong's hometown of Austin, Texas.

"We were mesmerized and riveted by some of his answers," she told CBS.

While the interview was revealing, Winfrey said, his demeanor surprised her. "He did not come clean in the manner that I expected," she said without elaborating.

Asked whether she thought it was difficult for him to "come clean" to her, Winfrey responded, "Yes. I think the entire interview was difficult."

Public takes shots at Armstrong in advance of Oprah interview

It was not immediately clear why Armstrong apparently chose to acknowledge doping after years of denials.

Juliet Macur, the New York Times reporter who broke the news on January 4 that Armstrong was considering an admission of doping, said the athlete is too driven to accept life without sports.

"He has had (several months) to think about how he is lonely, how he doesn't have the adulation of fans at the finish line and nobody to beat right now," she said. "And it's driving him nuts."

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Armstrong has been seeking to participate in triathlons sanctioned by U.S. Olympic authorities. Armstrong excelled at triathlons as a teenager and went back to the sport after retiring from cycling. He has been banned from officially sanctioned events.

Armstrong in talks to return Postal Service money

Paul Willerton, who raced with Armstrong in the early 1990s, said any confession would be "just a starting point" for the cycling star.

"There are a lot of people still lying," Willerton said, naming former Armstrong consultant Dr. Michele Ferrari, and Johan Bruyneel, the onetime director of Armstrong's U.S. Postal Service team. "These guys are still perpetrating the lies and deception that Lance ruled over, and Lance holds the keys. He wants his control back, and he desperately wants to be liked by the American public. And you can't have it all."

The USADA suspended Ferrari for life in July, naming him as part of a large-scale doping conspiracy. Bruyneel is battling similar charges by the agency and said in October that he was "stunned" that its findings on Armstrong revealed details of the allegations against him.

Livestrong is also a consideration.

In October, Armstrong resigned as chairman of the charity he founded "to spare the foundation any negative effects as a result of controversy surrounding my cycling career," according to a statement posted to the group's website at the time. A few weeks later, he left the board entirely amid concerns that his involvement was harming the charity.

Cancer survivor: No excuse not to live strong

On Monday, he visited the charity and "expressed his regret for the stress the team suffered in recent years as a result of the controversy surrounding his cycling career," the organization said in a statement.

"Inspired by the people with cancer whom we serve, we feel confident and optimistic about the Foundation's future and welcome an end to speculation," the group said.

Meanwhile, the cycling world is eagerly -- and in some cases, perhaps, anxiously -- awaiting to hear what Armstrong has to say.

As the World Anti-Doping Agency noted, Armstrong could begin to redeem himself by speaking out about others in cycling with deep involvement in doping.

That's what former cyclist John Eustice expects when Armstrong speaks.

"I think what he'll do is explain how it all works," he said.

Willerton agreed, saying it's one last way for Armstrong to control the narrative swirling around him.

"He's cornered in the sense that he wants to maintain control and he knows that he holds the keys to the people around him who were complicit in what he did," Willerton said. "And that's really the most valuable thing he has to offer at this point."

However, on Tuesday, a source familiar with the matter denied to CNN a report in The New York Times that Armstrong was planning to testify against several powerful people in cycling who have facilitated doping.

The admissions could also have legal ramifications for Armstrong.

Claims, attacks, legacy: 12 Armstrong quotes to know

SCA Promotions paid Armstrong millions for his Tour de France wins, and now wants its money back. Armstrong sued the company after it raised questions about allegations involving him, and testified under oath that he'd never doped, attorney Jeff Tillotson said Wednesday.

"No matter what he says tomorrow night, based on the evidence we have, we have a compelling legal case for the return of the money we paid him," he said. "But we're specifically looking to see which of the doping allegations that we raised and developed in our case he's going to acknowledge as true."

Meanwhile, the federal government is evaluating whether it will intervene in a whistle-blower lawsuit filed by a former Armstrong teammate. The lawsuit accuses managers for the team they both raced for of defrauding the federal government of millions of dollars because they knew about the drug use and didn't do anything.

A source familiar with the matter confirmed to CNN that lawyers for Armstrong are in discussions with the Justice Department regarding the case. The government has until Thursday to intervene, not intervene or ask for an extension, the source said.

The Justice Department declined Tuesday to comment on potential civil action against Armstrong, saying the whistle-blower suit is under court seal.

A spokesman for the U.S. Postal Service told CNN it could not discuss any of the legal issues associated with Armstrong and their prior relationship.

CNN's Kevin Bohn contributed to this report.