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London (CNN) -- Officers arrested six people Wednesday over what London's Metropolitan Police is calling a separate phone-hacking conspiracy at Rupert Murdoch's defunct News of the World newspaper.

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Dozens of people, including Murdoch protege Rebekah Brooks and Andy Coulson, a former adviser to prime Minister David Cameron, have already been arrested and charged with phone hacking and related crimes.

Police say Wednesday's arrests are part of a separate conspiracy to hack phones from 2005 to 2006 at the News of the World.

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Three men and two women were arrested in London and one woman in Cheshire, in northern England.

Murdoch closed the Sunday tabloid, one of the world's best-selling English-language newspapers, in 2011 over the phone-hacking scandal.

Three police investigations were established in the wake of the scandal, looking into allegations of phone hacking, bribery of public officials and computer hacking.

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Brooks and Coulson, both former News of the World editors, were charged last year. Brooks later become chief executive of News International, a UK subsidiary of Murdoch's News Corp. empire. Coulson went on to become Cameron's director of communications before resigning early in 2011.

The hacking scandal prompted Cameron to set up an independent judge-led inquiry -- named for Lord Justice Leveson, its chairman -- to make recommendations on journalistic ethics and examine the relationship of the press with the public, police and politicians.